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Short information on the offered enzyme classes
Carboxylesterases
Carboxylesterases, a subset of hydrolases, find broad application in organic synthesis. Due to their high regio- and stereoselectivity they are used for the selective cleavage of protecting groups and for the kinetic resolution of esters of racemic alcohols or carboxylic acids.
They require no cofactors and are stable and active when organic solvents are added to the reaction mixture.
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Baeyer-Villiger monooxygenases
Baeyer-Villiger monooxygenases catalyse the oxidation of ketones to the corresponding esters or lactones using molecular oxygen under ambient conditions.
They require NAD(P)H as cofactor, therefore they are often applied as whole-cell catalysts or in combination with a cofactor recycling system.
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Amine transaminases
Amine transaminases catalyze the transfer of an amino group from a primary amine to a (prochiral) ketone or aldehyde. Their high enantioselectivity enables their application in the resolution of racemic amines or the synthesis of chiral amines from inexpensive ketones.
They require pyridoxal-5'-phosphate as cofactor.
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